The model has the potential to transform the ability to study telomere biology, learn more about human aging, and ultimately help people preserve better health as they age.

Early findings showed EXG-34217 elongated telomere length ex vivo. The Food and Drug Administration (FDA) has granted Orphan Drug designation to EXG-34217 for the treatment of telomere biology ...

On the flipside, if telomeres are too long, it can also spell trouble because cancer cells require long telomeres to become longer lived, ‘immortal,’” says Mia Levine, associate professor of biology ...

A new computational tool infers changes occurring at the ends of the chromosomes housing our DNA. It does so by detecting structural alterations in cells and tissues captured in images taken of ...

Scientists have recently completed a lengthy study in which over 200 people with premature aging disorders that are caused by unusually short telomeres were followed for 20 years. Telomeres are the ...

Recent studies are changing what scientists have long thought about telomeres, which are repetitive sequences of DNA that cap the ends of chromosomes. Telomeres get shorter with each round of cell ...

This paper, published in December 1994, describes a polymerase chain reaction (PCR)-based assay for measuring the activity of telomerase, the enzyme that controls telomere length. But more important, ...

Critically shortened telomeres are known to be a key limiting factor in successful CAR T-cell immunotherapy, with cells from older patients tending to have shorter telomeres with reduced dividing ...

Age is just a number; however, biological age is a bit more involved than how many birthdays you have had. “Chronological age ...

Edited by: Karen Young Kreeger C.M. Counter, J. Gupta, C.B. Harley, B. Leber, S. Bacchetti, "Telomerase activity in normal leukocytes and hematologic malignancies ...