Early findings showed EXG-34217 elongated telomere length ex vivo. The Food and Drug Administration (FDA) has granted Orphan Drug designation to EXG-34217 for the treatment of telomere biology ...

This paper, published in December 1994, describes a polymerase chain reaction (PCR)-based assay for measuring the activity of telomerase, the enzyme that controls telomere length. But more important, ...

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres — regions of repetitive DNA sequences and a protein structure — protect the tips of chromosomes from damage. Every ...

Critically shortened telomeres are known to be a key limiting factor in successful CAR T-cell immunotherapy, with cells from older patients tending to have shorter telomeres with reduced dividing ...

Researchers have found a way to trap telomerase, the enzyme cancer cells rely on for endless division, in a stalled and non-productive state. The discovery, published in Nature Communications, used ...

Why do our cells age? Part of the answer is hidden at the very ends of our chromosomes, where telomeres are located. These ...

Edited by: Karen Young Kreeger C.M. Counter, J. Gupta, C.B. Harley, B. Leber, S. Bacchetti, "Telomerase activity in normal leukocytes and hematologic malignancies ...