Understanding the material basis of adaptive evolution has been a central goal in biology dating back to at least the time of Darwin. One focus of current debates is whether adaptive evolution relies ...

Osaka, Japan - Gross chromosomal rearrangements—where portions of the genome become moved, deleted, or inverted—can lead to cell death and diseases such as cancer in complex multicellular organisms.

Researchers in Japan find that B-cell acute lymphoblastic leukemia with NUTM1 gene rearrangements is a unique form of the ...

The prognosis for patients with myeloid/lymphoid neoplasms with FGFR1 rearrangements is poor, and treatment options are limited. In a phase II study of these patients, the overall complete response ...

Osaka, Japan – Despite a host of checks and balances that usually prevent harmful genetic mutations, sometimes mistakes happen, with serious consequences. Now, researchers from Japan elucidate how a ...

Researchers have uncovered how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. The study reveals that during DNA repair, segments ...

Recent studies have highlighted the improved capability of long-read sequencing to detect structural variation in the human genome. However, most of the existing methods were designed to detect ...

The Journal of Clinical Oncology podcast, hosted by Dr. Davide Soldato, presents analyses and discussions centered on the latest findings published in ASCO’s esteemed Journal of Clinical Oncology.

Novel, sensitive simplex and multiplex assays for KRAS and NRAS mutation detection. A clinico-biological Risk Assessment Model for VTE in ambulatory patients with lung adenocarcinoma on chemotherapy ...