Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice.

Researchers have found a way to trap telomerase, the enzyme cancer cells rely on for endless division, in a stalled and non-productive state. The discovery, published in Nature Communications, used ...

Exceptional measures of efficacy observed in THIO-101 Phase 2 trial to date include disease control, response rates, and survival data well above ...

Scientists investigate human telomere length to elucidate aging and diseases such as cancer and neurodegenerative disorders. In normal mammalian cells, a small telomeric DNA segment is lost after each ...

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage. Every ...

As the rope of a chromosomes replicates, it frays at the ends. No problem: A chromosome's ends have extra twine so that fraying doesn't reach into the body of the rope where the important information ...

Why do our cells age? Part of the answer is hidden at the very ends of our chromosomes, where telomeres are located. These ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

A day in the life of DNA can be rough. It gets yanked across a dividing cell, zapped by radiation, and assaulted by chemicals. Luckily, cells have developed a complex set of repair mechanisms to ...